Exogene is a techbio startup using deep learning to unlock the discovery of innovative
TCR-based therapies for cancer treatment
Why
Human T-cells use T-cell receptors to eliminate diseased cells. This natural phenomenon can be harnessed for the development of TCR-based therapies to eradicate solid tumors. However, safe, high-affinity TCRs against cancer targets are rare and hard to identify using traditional wet-lab methods.
Our generative AI platform enables comprehensive mining of the TCR sequence space to discover completely novel, high-affinity and non-cross-reactive TCRs against targets shared across patients and tumor types.
Our Team
Federico Paoletti
CEO & Co-Founder
Andrea Mambrini
CTO & Co-Founder
Sebastian was the scientific mastermind behind the T cell engager programmes at Immatics (NASDAQ: IMTX). He spearheaded IMA401 and IMA402 from discovery all the way to first-in-human clinical trials, and unlocked the $150M upfront deal with BMS. Sebastian brings key scientific and commercial experience to help us develop and advance our assets towards the clinic.
Sebastian Bunk
Head of Pre-clinical Development
Muhammad holds a PhD in Mathematical Biology and Biophysical Chemistry from the University of Warwick. Over the last decade, he has worked on a broad range of protein engineering and structural biology projects at the interface of Physics, Chemistry and Biology. Prior to joining Exogene, he had been working on developing novel methods for the study and diagnostics of the SARS-CoV-2 virus.
Muhammad Hasan
Senior Director of R&D
Giovanni Mazzocco
Senior Computational Biologist
Jan-Gert is a protein biochemist with a PhD in Biology from the University of York. He previously worked at Memorial Sloan Kettering Cancer Center (MSKCC) developing in vitro assays to study how the DNA replication machinery deals with obstacles such as DNA damage and protein roadblocks to maintain genome integrity.
Jan-Gert Brüning
Principal Scientist
Alex is an experienced machine learning expert specialising in AI for biomedical research. At Ardigen, he served as a SCRUM master and developed models to predict peptide-HLA and TCR-pHLA binding. During his PhD at the Warsaw University of Technology, he focused on in-silico modelling of antigen recognition using machine learning.
Alexander Myronov
Senior Machine Learning Scientist
James Ravenscroft
Senior Operations Manager
Ryan is an experienced machine learning scientist with a PhD in Chemistry from Cornell University. He joined Exogene from the machine learning group at Bayer and his recent work there was published at ICML. He previously worked at Intel, and in his spare time he participates in machine learning competitions.
Ryan Henderson
Senior Machine Learning Scientist
Foram is a cell biologist and immunologist with over five years of experience in oncology and immunotherapy. She earned her PhD from the University of Plymouth and has since contributed to cutting-edge research at Scancell, where she played a pivotal role in advancing bispecific T-cell engager programs through both in vitro and in vivo preclinical development.
Foram Dave
Senior Scientist
Amanda is an experienced immunologist with expertise in protein science and cell biology. She holds a PhD in Biochemistry and Molecular Biology from Monash University (Australia) and she has previously developed TCR bi-specifics for the treatment of cancers and infectious diseases at Immunocore, a top TCR company.
Amanda Woon
Consultant
Sahan holds a PhD in Systems Engineering and Synthetic Biology from the University of Warwick. He developed the SpyPhage Platform that enables the rapid cell-free production and post-translational modification of bacteriophages for phage therapy. His current research spans the fields of synthetic biology, phage engineering and machine learning-led optimisations of cell-free TXTL systems.
Sahan Liyanagedera
Consultant
Livio is the co-founder of Vaxess Technologies, where he has pioneered a novel vaccine patch, raised over $80 million in funding, and collaborated with AstraZeneca on mRNA vaccine technologies. Before Vaxess, he worked at the United Nations, implementing silk production programs in Asia. Livio was named in the 2014 Forbes 30 under 30 list and holds a Masters in Public Policy from Harvard Kennedy School.
Livio Valenti
Commercial advisor
Paul Nathan
Clinical Advisor
Featured
Global Roundup: Exogene Secures Funding to Support TCR Discovery
April 28th, 2022
U.K.-based Exogene, which is developing novel T-cell receptor-based cell therapies, secured $2 million in new funding to help advance the development of its artificial intelligence (AI) platform for T-cell receptor discovery…
Email:
info@exogene.co.uk
Reg. Number:
12293407
Address:
Wood Centre for Innovation, Stansfeld Park, Quarry Road, Headington, Oxford, OX3 8SB
