Unlocking curative 
TCR-based therapies

Exogene is a techbio startup using deep learning to unlock the discovery of innovative 

TCR-based therapies for cancer treatment



Human T-cells use T-cell receptors to eliminate diseased cells. This natural phenomenon can be harnessed for the development of TCR-based therapies to eradicate solid tumors. However, safe, high-affinity TCRs against cancer targets are rare and hard to identify using traditional wet-lab methods.    

Our generative AI platform enables comprehensive mining of the TCR sequence space to discover completely novel, high-affinity and non-cross-reactive TCRs against targets shared across patients and tumor types.

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Our Team


Federico is a computational biologist with deep expertise in mathematical modelling and molecular biophysics. He holds a PhD in Molecular and Computational Oncology from the University of Oxford and has previously worked at the World Health Organization assessing cancer prevention strategies.

Federico Paoletti

CEO & Co-Founder


Andrea is an experienced machine learning scientist. He holds a PhD in Bio-Inspired Computation and has several years of experience building AI. He previously led the ML team at Portent.io (acquired by Yougov) and has worked at the European Space Agency, Honda Research Institute and Vodafone.

Andrea Mambrini

CTO & Co-Founder


Muhammad holds a PhD in Mathematical Biology and Biophysical Chemistry from the University of Warwick. Over the last decade, he has worked on a broad range of protein engineering and structural biology projects at the interface of Physics, Chemistry and Biology. Prior to joining Exogene, he had been working on developing novel methods for the study and diagnostics of the SARS-CoV-2 virus.

Muhammad Hasan

Director of R&D


Claudia holds a DPhil in Oncology from the University of Oxford. She has worked on multiple projects across chemistry and biology including industrial placements at Isomerase and AstraZeneca. DPhil research focussed on developing novel fluorine-18 labelled PET imaging agents targeting proteins of the DNA damage response.

Claudia Fraser

Research Associate


Ryan is an experienced machine learning scientist with a PhD in Chemistry from Cornell University. He joined Exogene from the machine learning group at Bayer and his recent work there was published at ICML. He previously worked at Intel, and in his spare time he participates in machine learning competitions.

Ryan Henderson

Senior Machine Learning Scientist


Jan-Gert is a protein biochemist with a PhD in Biology from the University of York. He previously worked at Memorial Sloan Kettering Cancer Center (MSKCC) developing in vitro assays to study how the DNA replication machinery deals with obstacles such as DNA damage and protein roadblocks to maintain genome integrity.

Jan-Gert Brüning

Senior Protein Scientist


Amanda is an experienced immunologist with expertise in protein science and cell biology. She holds a PhD in Biochemistry and Molecular Biology from Monash University (Australia) and she has previously developed TCR bi-specifics for the treatment of cancers and infectious diseases at Immunocore, a top TCR company.

Amanda Woon



Sahan holds a PhD in Systems Engineering and Synthetic Biology from the University of Warwick. He developed the SpyPhage Platform that enables the rapid cell-free production and post-translational modification of bacteriophages for phage therapy. His current research spans the fields of synthetic biology, phage engineering and machine learning-led optimisations of cell-free TXTL systems.

Sahan Liyanagedera



Ricardo is a world expert in wet-lab methods for high-throughput screening of TCR-target pairs. He is a Principal Investigator at the University of Oxford and he has published in high-profile journals such as Nature Immunology, Cell and PNAS.

Ricardo Fernandes

Scientific Advisor


Alasdair has extensive experience negotiating and managing AI-driven co-development partnerships in the biopharmaceutical industry. He is a Founding Partner at Selvedge Venture and former director of deep-tech venture investments at Leaps by Bayer.

Alasdair Thong

Commercial Advisor






Oxford BioEscalator, Innovation Building, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, United Kingdom